Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

MURAL investigators

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Abstract

Neuroendocrine prostate cancer is an aggressive disease subtype associated with poor patient outcome. Fernandes et al. demonstrate that a microRNA, miR-194, promotes the emergence of neuroendocrine features in prostate cancer cells by targeting genes that regulate epithelial-neuroendocrine plasticity. Inhibiting miR-194 suppresses the growth of neuroendocrine prostate cancer models.

Original languageEnglish
Article number108585
JournalCell Reports
Volume34
Issue number1
DOIs
Publication statusPublished - 5 Jan 2021

Keywords

  • FOXA1
  • lineage plasticity
  • miR-194
  • microRNA
  • neuroendocrine prostate cancer
  • post-transcriptional gene regulation
  • prostate cancer
  • transdifferentiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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