Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study

Julien Bensalem, Stéphanie Dudonné, Nicole Etchamendy, Hermine Pellay, Camille Amadieu, David Gaudout, Séverine Dubreuil, Marie-Eve Paradis, Sonia Pomerleau, Lucile Capuron, Carol Hudon, Sophie Layé, Yves Desjardins, Véronique Pallet

Research output: Contribution to journalArticle

Abstract

Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. The present study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary outcome was the CANTAB Paired Associate Learning (PAL), a visuospatial learning and episodic memory test. Secondary outcomes included verbal episodic and recognition memory (VRM) and working memory (SSP). There was no significant effect of PEGB on the PAL on the whole cohort. Yet, PEGB supplementation improved VRM free recall. Stratifying the cohort in quartiles based on PAL at baseline revealed a subgroup with advanced cognitive decline (decliners) who responded positively to the PEGB. In this group, PEGB consumption was also associated with a better VRM delayed recognition. In addition to a lower polyphenol consumption, the urine metabolomic profile of decliners revealed that they excreted more metabolites. Urinary concentrations of specific flavan-3-ols metabolites were associated, at the end of the intervention, with the memory improvements. Our study demonstrates that PEGB improves age-related episodic memory decline in individuals with the highest cognitive impairments.

LanguageEnglish
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
DOIs
Publication statusE-pub ahead of print - 19 Jul 2018
Externally publishedYes

Keywords

  • Journal Article

Cite this

Bensalem, Julien ; Dudonné, Stéphanie ; Etchamendy, Nicole ; Pellay, Hermine ; Amadieu, Camille ; Gaudout, David ; Dubreuil, Séverine ; Paradis, Marie-Eve ; Pomerleau, Sonia ; Capuron, Lucile ; Hudon, Carol ; Layé, Sophie ; Desjardins, Yves ; Pallet, Véronique. / Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance : a bicentric double-blind, randomized, placebo-controlled clinical study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2018.
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Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance : a bicentric double-blind, randomized, placebo-controlled clinical study. / Bensalem, Julien; Dudonné, Stéphanie; Etchamendy, Nicole; Pellay, Hermine; Amadieu, Camille; Gaudout, David; Dubreuil, Séverine; Paradis, Marie-Eve; Pomerleau, Sonia; Capuron, Lucile; Hudon, Carol; Layé, Sophie; Desjardins, Yves; Pallet, Véronique.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 19.07.2018.

Research output: Contribution to journalArticle

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AU - Dudonné, Stéphanie

AU - Etchamendy, Nicole

AU - Pellay, Hermine

AU - Amadieu, Camille

AU - Gaudout, David

AU - Dubreuil, Séverine

AU - Paradis, Marie-Eve

AU - Pomerleau, Sonia

AU - Capuron, Lucile

AU - Hudon, Carol

AU - Layé, Sophie

AU - Desjardins, Yves

AU - Pallet, Véronique

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