Polyphénols extraits de petits fruits et déclin cognitif lié à l’âge : résultats de l’étude Neurophenols.

Translated title of the contribution: Polyphenols from berry extracts and age-related cognitive decline: results from the Neurophenols study.

Julien Bensalem, Pauline Lafenetre, Veronique Pallet

Research output: Contribution to conferencePaper

Abstract

Aging is characterized by memory deficits, associated with brain plasticity impairment. The age-related cognitive decline has been evidenced both in animals and human. Polyphenols from berries, were suggested to modulate cerebral plasticity and cognitive processes. The Neurophenols project developed a polyphenol-rich mix extracted from grape and blueberry (PEGB), with high concentrations of flavonoids and objectified its beneficial effect on the age-related cognitive decline.
At the preclinical level, in mice, hippocampal-dependent learning and memory alterations linked to aging are recovered by a PEGB consumption via the diet. The PEGB supplementation in aged mice, also restore the expression level of some genes marker of synaptic plasticity and neurogenesis, processes underlying memory performances.
These promising results in aged mice provide positive arguments on the benefits of PEGB on memory during human aging. An interventional study on the effect of PEGB on memory of elderly was also conducted as part of the Neurophenols project.
Translated title of the contributionPolyphenols from berry extracts and age-related cognitive decline: results from the Neurophenols study.
Original languageFrench
Pages67-82
Publication statusPublished or Issued - Mar 2018
EventAlimentation périnatale, alimentation des séniors: spécificités, impact du microbiote: INRA, Innovations Agronomiques 65 - Paris, France
Duration: 28 Mar 201828 Mar 2018
https://www6.inrae.fr/ciag/Revue/Volumes-publies-en-2018/Volume-65-Mars-2018

Conference

ConferenceAlimentation périnatale, alimentation des séniors: spécificités, impact du microbiote
CountryFrance
CityParis
Period28/03/1828/03/18
Internet address

Keywords

  • Flavonoids
  • Grape
  • Blueberry
  • Memory
  • Ageing
  • Nutrition

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