Polyandric acid A, a clerodane diterpenoid from the australian medicinal plant dodonaea polyandra, attenuates pro-inflammatory cytokine secretion in vitro and in vivo

Bradley S. Simpson, Xianling Luo, Maurizio Costabile, Gillian E. Caughey, Jiping Wang, David J. Claudie, Ross A. McKinnon, Susan J. Semple

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15 Citations (Scopus)

Abstract

Dodonaea polyandra is a medicinal plant used traditionally by the Kuuku I'yu (Northern Kaanju) indigenous people of Cape York Peninsula, Australia. The most potent of the diterpenoids previously identified from this plant, polyandric acid A (1), has been examined for inhibition of pro-inflammatory cytokine production and other inflammatory mediators using well-established acute and chronic mouse ear edema models and in vitro cellular models. Topical application of 1 significantly inhibited interleukin-1β production in mouse ear tissue in an acute model. In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ionomycin showed a significant reduction in IL-6 secretion. The present study provides evidence that the anti-inflammatory properties of 1 are due to inhibition of pro-inflammatory cytokines associated with skin inflammation and may be useful in applications for skin inflammatory conditions including psoriasis and dermatitis.

Original languageEnglish
Pages (from-to)85-91
JournalJournal of Natural Products
Volume77
Issue number1
DOIs
Publication statusPublished - 24 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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