Plasticity of gastrointestinal vagal afferent satiety signals

A. J. Page, S. J. Kentish

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The vagal link between the gastrointestinal tract and the central nervous system (CNS) has numerous vital functions for maintaining homeostasis. The regulation of energy balance is one which is attracting more and more attention due to the potential for exploiting peripheral hormonal targets as treatments for conditions such as obesity. While physiologically, this system is well tuned and demonstrated to be effective in the regulation of both local function and promoting/terminating food intake the neural connection represents a susceptible pathway for disruption in various disease states. Numerous studies have revealed that obesity in particularly is associated with an array of modifications in vagal afferent function from changes in expression of signaling molecules to altered activation mechanics. In general, these changes in vagal afferent function in obesity further promote food intake instead of the more desirable reduction in food intake. It is essential to gain a comprehensive understanding of the mechanisms responsible for these detrimental effects before we can establish more effective pharmacotherapies or lifestyle strategies for the treatment of obesity and the maintenance of weight loss.

LanguageEnglish
Article numbere12973
JournalNeurogastroenterology and Motility
Volume29
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Keywords

  • gastrointestinal tract
  • obesity
  • vagal afferents

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

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Plasticity of gastrointestinal vagal afferent satiety signals. / Page, A. J.; Kentish, S. J.

In: Neurogastroenterology and Motility, Vol. 29, No. 5, e12973, 01.05.2017.

Research output: Contribution to journalReview article

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AU - Kentish, S. J.

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