Phosphorylation and signal transduction pathways in translational control

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Abstract

Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is regulated by extracellular stimuli such as hormones and by the levels of certain nutrients within cells. This control involves several well-understood signaling pathways and protein kinases, which regulate the phosphorylation of proteins that control the translational machinery. These pathways include the mechanistic target of rapamycin complex 1 (mTORC1), its downstream effectors, and the mitogen-activated protein (MAP) kinase (extracellular ligand-regulated kinase [ERK]) signaling pathway. This review describes the regulatory mechanisms that control translation initiation and elongation factors, in particular the effects of phosphorylation on their interactions or activities. It also discusses current knowledge concerning the impact of these control systems on the translation of specific mRNAs or subsets of mRNAs, both in physiological processes and in diseases such as cancer.

Original languageEnglish
Article numbera033050
JournalCold Spring Harbor perspectives in biology
Volume11
Issue number7
Early online date29 Jun 2018
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • Journal Article

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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