Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action

Ma Li Wong

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The terms pharmacogenetics and pharmacogenomics are frequently used interchangeably. Pharmacogenetics studies genetically based inter-individual variability in response to drugs and susceptibility to drug-induced side effects. Pharmacogenomics is a new area of medical science that integrates genomics and therapeutics. The human genome sequence has been the starting point of pharmacogenomics, and it leads to a better understanding of interactions between drugs and organisms. Pharmacogenomics utilizes high-throughput technologies, which have been developed to make it possible for researchers to harness the wealth of genomic data toward the goal of improving therapeutics. It involves the systematic identification of all human genes and gene products, the study of human genetic variations, combined with changes in gene and protein expression over time, in health and disease states. This new area of investigation has provoked a paradigm shift in clinical and basic research: the prevalent reductionist approach has been challenged. Currently, studies focusing on one or a couple of genes are giving way to microarray experiments that simultaneously query multiple genes and systems. There has been considerable expectation in the potential impact of pharmacogenomics in the discovery of innovative, effective, and individualized treatments. In this chapter we discuss the complex issues facing pharmacogenomics research and the state of its art.

Original languageEnglish
Title of host publicationBiology of Depression
Subtitle of host publicationFrom Novel Insights to Therapeutic Strategies
PublisherJohn Wiley and Sons
Pages855-877
Number of pages23
ISBN (Print)3527307850, 9783527307852
DOIs
Publication statusPublished - 29 Jan 2008

Keywords

  • Drugs
  • Experiments
  • Microarray
  • Pharmacogenomics
  • Susceptibility

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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