Perinatal nutrition interventions and post-partum depressive symptoms

Research output: Contribution to journalReview article

7 Citations (Scopus)


Background Postpartum depression (PPD) is the most prevalent mood disorder associated with childbirth. No single cause of PPD has been identified, however the increased risk of nutritional deficiencies incurred through the high nutritional requirements of pregnancy may play a role in the pathology of depressive symptoms. Three nutritional interventions have drawn particular interest as possible non-invasive and cost-effective prevention and/or treatment strategies for PPD; omega-3 (n-3) long chain polyunsaturated fatty acids (LCPUFA), vitamin D and overall diet. Methods We searched for meta-analyses of randomised controlled trials (RCT's) of nutritional interventions during the perinatal period with PPD as an outcome, and checked for any trials published subsequently to the meta-analyses. Results Fish oil: Eleven RCT's of prenatal fish oil supplementation RCT's show null and positive effects on PPD symptoms. Vitamin D: no relevant RCT's were identified, however seven observational studies of maternal vitamin D levels with PPD outcomes showed inconsistent associations. Diet: Two Australian RCT's with dietary advice interventions in pregnancy had a positive and null result on PPD. Limitations With the exception of fish oil, few RCT's with nutritional interventions during pregnancy assess PPD. Conclusions Further research is needed to determine whether nutritional intervention strategies during pregnancy can protect against symptoms of PPD. Given the prevalence of PPD and ease of administering PPD measures, we recommend future prenatal nutritional RCT's include PPD as an outcome.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalJournal of Affective Disorders
Publication statusPublished - 15 Dec 2017


  • Depression
  • Diet
  • Intervention
  • Nutrition
  • Postpartum

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this