Peptide antimicrobial agents

Håvard Jenssen, Pamela Hamill, Robert E.W. Hancock

Research output: Contribution to journalReview article

1501 Citations (Scopus)

Abstract

Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct and indirect microbicidal activities against such pathogens. The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides. Peptides with antifungal and antiparasitic activities are discussed in less detail, although the broad-spectrum activities of such peptides indicate that they are important host defense molecules. Knowledge regarding the relationship between peptide structure and function as well as their mechanism of action is being applied in the design of antimicrobial peptide variants as potential novel therapeutic agents.

Original languageEnglish
Pages (from-to)491-511
Number of pages21
JournalClinical Microbiology Reviews
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Jul 2006

ASJC Scopus subject areas

  • Epidemiology
  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

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