Pattern of polyphenol intake and the long-term risk of dementia in older persons

Sophie Lefèvre-Arbogast, David Gaudout, Julien Bensalem, Luc Letenneur, Jean François Dartigues, Boris P. Hejblum, Catherine Féart, Cécile Delcourt, Cécilia Samieri

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. Methods: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. Results: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models. Conclusions: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.

LanguageEnglish
Pagese1979-e1988
JournalNeurology
Volume90
Issue number22
DOIs
Publication statusPublished - 29 May 2018
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lefèvre-Arbogast, S., Gaudout, D., Bensalem, J., Letenneur, L., Dartigues, J. F., Hejblum, B. P., ... Samieri, C. (2018). Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology, 90(22), e1979-e1988. https://doi.org/10.1212/WNL.0000000000005607
Lefèvre-Arbogast, Sophie ; Gaudout, David ; Bensalem, Julien ; Letenneur, Luc ; Dartigues, Jean François ; Hejblum, Boris P. ; Féart, Catherine ; Delcourt, Cécile ; Samieri, Cécilia. / Pattern of polyphenol intake and the long-term risk of dementia in older persons. In: Neurology. 2018 ; Vol. 90, No. 22. pp. e1979-e1988.
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Lefèvre-Arbogast, S, Gaudout, D, Bensalem, J, Letenneur, L, Dartigues, JF, Hejblum, BP, Féart, C, Delcourt, C & Samieri, C 2018, 'Pattern of polyphenol intake and the long-term risk of dementia in older persons', Neurology, vol. 90, no. 22, pp. e1979-e1988. https://doi.org/10.1212/WNL.0000000000005607

Pattern of polyphenol intake and the long-term risk of dementia in older persons. / Lefèvre-Arbogast, Sophie; Gaudout, David; Bensalem, Julien; Letenneur, Luc; Dartigues, Jean François; Hejblum, Boris P.; Féart, Catherine; Delcourt, Cécile; Samieri, Cécilia.

In: Neurology, Vol. 90, No. 22, 29.05.2018, p. e1979-e1988.

Research output: Contribution to journalArticle

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AU - Dartigues, Jean François

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N2 - Objective: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. Methods: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk. Results: The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%-68%, p for trend <0.01) in multivariate models. Conclusions: In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.

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Lefèvre-Arbogast S, Gaudout D, Bensalem J, Letenneur L, Dartigues JF, Hejblum BP et al. Pattern of polyphenol intake and the long-term risk of dementia in older persons. Neurology. 2018 May 29;90(22):e1979-e1988. https://doi.org/10.1212/WNL.0000000000005607