Patient perceptions of treatment-free remission in chronic myeloid leukemia

Lucia A. Villemagne Sanchez, Clare O’Callaghan, Karla Gough, Karen Hall, Yoshihisa Kashima, John F. Seymour, Penelope Schofield, David Ross

Research output: Contribution to journalArticle

12 Citations (Scopus)


Around half of patients with chronic myeloid leukemia (CML) who achieve a stable deep molecular response would remain in treatment-free remission (TFR) if their tyrosine kinase inhibitors (TKIs) were stopped. TFR is increasingly becoming a goal of treatment. Eighty-seven patients answered a survey exploring patient perceptions of TFR, incorporating CML-specific factors (disease history, treatment toxicity, and adherence) and questions concerning health beliefs. 81% of participants (95% CI: 72%–89%) indicated that they would be willing to attempt TFR. No demographic or CML-related variable in the survey was significantly associated with willingness. In qualitative analysis, the commonest motivations for TFR included TKI toxicity (n = 26) and convenience (n = 18). The leading reason for reluctance was fear of consequences of stopping TKI (n = 16). Reluctance was often associated with needs for additional information or incomplete understanding of the current data. Understanding patient motivations and concerns is important if TFR is to become a part of CML management.

Number of pages10
JournalLeukemia and Lymphoma
Issue number2
Publication statusPublished - 1 Feb 2018


  • Chronic myeloid leukemia
  • quality of life
  • treatment-free remission
  • tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Villemagne Sanchez, L. A., O’Callaghan, C., Gough, K., Hall, K., Kashima, Y., Seymour, J. F., ... Ross, D. (2018). Patient perceptions of treatment-free remission in chronic myeloid leukemia. Leukemia and Lymphoma, 59(2), 406-415.