Pathogenesis and Diagnosis of Viral Infections of the Nervous System

Edwina J. Wright, Bruce J. Brew, Steve L. Wesselingh

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Viral infections of the central nervous system are common and manifest as both acute and chronic illnesses in adults and children. In this article we review cells of the healthy nervous system, the types of viruses that infect them, the nervous system's specialized immune response to viral infections, and how this host-virus interaction influences the clinical examination findings. We discuss a diagnostic approach to viral infections of the nervous system, which includes the importance of taking a detailed history of the presenting illness that examines possible routes of exposure to the virus. This history when coupled with the examination findings and targeted investigations should enable the clinician to diagnose both common and obscure viral infections of the nervous system.

Original languageEnglish
Pages (from-to)617-633
Number of pages17
JournalNeurologic Clinics
Issue number3
Publication statusPublished - Aug 2008

ASJC Scopus subject areas

  • Clinical Neurology

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