Organochlorine levels in plasma and risk of multiple myeloma

Leah Weber, Kevin Song, Terry Boyle, Éric Gaudreau, Agnes Lai, Heather J. Sutherland, Alain LeBlanc, John J. Spinelli

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM). Methods: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls. Results: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio=7.44; 95% confidence interval=4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and b-hexachlorocyclohexane (b-HCCH) were identified as significant independent predictors of MM. Conclusion: Our study provides evidence that organochlorines contribute to the risk of MM.

LanguageEnglish
Pages911-916
Number of pages6
JournalJournal of Occupational and Environmental Medicine
Volume60
Issue number10
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Case-control study
  • Epidemiology
  • Multiple myeloma
  • Organochlorines
  • Polychlorinated biphenyls

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Weber, L., Song, K., Boyle, T., Gaudreau, É., Lai, A., Sutherland, H. J., ... Spinelli, J. J. (2018). Organochlorine levels in plasma and risk of multiple myeloma. Journal of Occupational and Environmental Medicine, 60(10), 911-916. https://doi.org/10.1097/JOM.0000000000001387