Hypertensive disorders of pregnancy (HDP) affect 4% to 9% of women and are among the leading causes of maternal and perinatal morbidity and mortality worldwide . In low-income countries where maternal mortality is high, HDP-related maternal death ranges from 9% of deaths in Asia and Africa to 26% in South America. In high-income countries where maternal mortality rates are lower and effective diagnosis and treatment are available, HDP still account for 16% of maternal deaths . The burden of maternal morbidity, perinatal morbidity and mortality, and costs to health care systems are even higher. There has been considerable interest in identifying modifiable risk factors, such as nutritional and lifestyle factors that might reduce the burden of HDP. Nutrition interventions, such as dietary modification and micronutrient supplementation, have been explored in relation to HDP risk and, given that obesity is associated with an increased risk of HDP, lifestyle 156interventions have also been investigated. In this chapter, following an overview of HDP and its pathogenesis, we examine the evidence relating to nutrition and HDP, and try to elucidate some of the mechanisms by which nutrition may influence HDP.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)