Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients

C C Blyth, S. C. Chen, M A Slavin, C Serena, Quoc Nguyen, Deborah Marriott, David Ellis, W. Meyer, T C Sorrell, Steven Wesselingh

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

131 Citations (Scopus)


OBJECTIVE: The purpose of this work was to identify differences in incidence, risk factors, microbiology, treatment, and clinical outcome of candidemia in neonates, children, and adults that might impact on management. PATIENTS AND METHODS: Cases of candidemia in Australia were identified prospectively by blood culture surveillance over 3 years. Episodes of candidemia in neonatal, pediatric, and adult age groups were analyzed and compared. RESULTS: Of 1005 incident cases, 33 occurred in neonates, 110 in children, and 862 in adults. The respective annual age-specific incidences were 4.4, 0.9, and 1.8 per 100,000 population. Prematurity and ICU admission were major risk factors in neonates. Hematologic malignancy and neutropenia were significantly more frequent in children than in neonates and adults. Diabetes, renal disease, hemodialysis, and recent surgery were more common in adults. Candidemia was attributed to a vascular access device in 58% of neonates, 70% of children, and 44% of adults. Candida albicans caused approximately 48% of cases in all of the age groups. Candida parapsilosis was significantly more common in neonates and children (42% and 38% vs 15%). Candida glabrata was infrequent in neonates and children (9% and 3% vs 17%). Significantly more isolates from children were susceptible to fluconazole compared with those from adults (95% vs 75%). Fluconazole-resistant candidal isolates were infrequent in all of the age groups. Neonates and children were more likely to receive amphotericin B compared with adults. Adults were more likely to receive fluconazole. Survival rates at 30 days were 78% in neonates, 90% in children, and 70% in adults. CONCLUSIONS: This study identifies significant differences in candidemia in neonates, children, and adults. Neonatologists and pediatricians must consider age-specific differences when interpreting adult studies and developing treatment and prevention guidelines
Original languageEnglish
Title of host publicationPediatrics
Place of PublicationCentre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmend, New South Wales 2145, Australia.
Number of pages9
Publication statusPublished or Issued - May 2009

Publication series



  • Adult
  • Amphotericin B
  • Antifungal Agents
  • Australia
  • Candida
  • Candida albicans
  • Candidiasis
  • Child
  • Child,Preschool
  • Comorbidity
  • DNA Fingerprinting
  • Female
  • Fluconazole
  • Humans
  • Incidence
  • Infant,Newborn
  • Infant,Premature
  • Male
  • Neoplasms
  • Neutropenia
  • Risk Factors
  • Seroepidemiologic Studies
  • Survival Rate
  • Systemic Inflammatory Response Syndrome
  • blood
  • drug therapy
  • epidemiology
  • genetics
  • microbiology
  • mortality
  • therapeutic use

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