Noninvasive ventilation in acute severe asthma: Current evidence and future perspectives

Kristin V. Carson, Zafar A. Usmani, Brian J. Smith

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


PURPOSE OF REVIEW: The use of noninvasive positive pressure ventilation (NPPV) is often employed for the management of acute respiratory failure as an alternative to endotracheal intubation and mechanical ventilation. However, evidence to support the application of NPPV use in patients with acute severe asthma is less known. RECENT FINDINGS: A paucity of evidence is available to support the use of NPPV as part of clinical care in patients with acute severe asthma. A number of small studies in adult and paediatric populations suggest that NPPV may have a beneficial role through improving respiratory rate and reducing the need for more invasive alternatives. Overall NPPV use appeared to be well tolerated with few reports of adverse events. SUMMARY: Available evidence is limited by a small number of published trials and lack of methodological rigour in existing study design. There is a need for well conducted clinical studies to establish accurate treatment efficacy, safety and cost-effectiveness, in both the adult and paediatric setting.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalCurrent Opinion in Pulmonary Medicine
Issue number1
Publication statusPublished or Issued - 1 Jan 2014


  • NIV
  • NPPV
  • asthma
  • noninvasive ventilation
  • status asthmaticus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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