Non-invasive tests of neurovascular function: Reduced responses in diabetes mellitus

Roderick A. Westerman, Robert E. Widdop, Craig Hogan, Paul Zimmet

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Painful transcutaneous electrical nerve stimulation (TENS) of the foot dorsum evoked axon reflex vasodilatation, measured by laser Doppler flowmetry. In addition, acetylcholine (ACh) and sodium nitrite (NaNO2) were iontophoresed to cause vasodilatation by endothelium dependent and independent mechanisms, respectively. Compared with healthy volunteers, diabetic patients with clinically diagnosed neuropathy showed reduced electrical axon reflex flare and ACh responses, but not NaNO2 responses. Such reduced cutaneous nocifensor functions may contribute to some symptoms and complications of diabetes mellitus.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished or Issued - 16 Oct 1987
Externally publishedYes


  • Acetylcholine
  • Axon reflex
  • Diabetes mellitus
  • Iontophoresis
  • Laser Doppler flowmetry
  • Neuropathy
  • Skin vasodilatation
  • Sodium nitrite

ASJC Scopus subject areas

  • Neuroscience(all)

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