Non-human primate dendritic cells

Shilpanjali Jesudason, Michael G. Collins, Natasha M. Rogers, Svjetlana Kireta, P. Toby H. Coates

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Non-human primates (NHP) are essential translational models for biomedical research. Dendritic cells (DC) are a group of antigen presenting cells (APC) that play pivotal roles in the immunobiology of health and disease and are attractive cells for adoptive immunother-apy to stimulate and suppress immunity. DC have been studied extensively in humans and mice but until recently, have not been well characterized in NHP. This review considers the available data about DC across a range of NHP species and summarizes the understanding of in vitro-propagated DC and in vivo-isolated DC, which is now established. It is clear that although NHP DC exist within the paradigm of human DC, there are important functional and phenotypic differences when compared with human DC subsets. These differences need to be taken into account when designing preclini-cal, translational studies of DC therapy using NHP models.

Original languageEnglish
Pages (from-to)217-228
Number of pages12
JournalJournal of Leukocyte Biology
Volume91
Issue number2
DOIs
Publication statusPublished - 1 Feb 2012
Externally publishedYes

Keywords

  • Growth factor mobilization
  • Immunotherapy
  • In vitro propagation
  • Translational research

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Jesudason, S., Collins, M. G., Rogers, N. M., Kireta, S., & Coates, P. T. H. (2012). Non-human primate dendritic cells. Journal of Leukocyte Biology, 91(2), 217-228. https://doi.org/10.1189/jlb.0711355