No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency

Claire M. Vajdic, Marina T. Van Leeuwen, Jennifer J. Turner, Ann M. McDonald, Angela C. Webster, Stephen McDonald, Jeremy R. Chapman, John M. Kaldor, Andrew E. Grulich

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human immunodeficiency virus (HIV) infection 1982-2004 (n = 17,175). National, population-based registries were linked and standardized incidence ratios (SIRs) were computed for each cohort and lymphoma subtype. Risk of diffuse large B-cell lymphoma was significantly increased after transplantation (SIR 17.83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma.

LanguageEnglish
Pages2732-2735
Number of pages4
JournalInternational Journal of Cancer
Volume127
Issue number11
DOIs
Publication statusPublished - 1 Dec 2010

Keywords

  • HIV
  • immunodeficiency
  • incidence
  • non-Hodgkin lymphoma
  • transplantation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Vajdic, C. M., Van Leeuwen, M. T., Turner, J. J., McDonald, A. M., Webster, A. C., McDonald, S., ... Grulich, A. E. (2010). No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency. International Journal of Cancer, 127(11), 2732-2735. https://doi.org/10.1002/ijc.25272