NF-κB signaling pathways: Role in nervous system physiology and pathology

Stefka Tasheva, Rosa M. Soler

Research output: Contribution to journalReview articlepeer-review

91 Citations (Scopus)

Abstract

Intracellular pathways related to cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that have recently emerged with an important role in these processes is nuclear factor- κB (NF-κB). The activity of this pathway leads to the nuclear translocation of the NF-κB transcription factors and the regulation of anti-apoptotic gene expression. Different stimuli can activate the pathway through different intracellular cascades (canonical, non-canonical, and atypical), contributing to the translocation of specific dimers of the NF-κB transcription factors, and each of these dimers can regulate the transcription of different genes. Recent studies have shown that the activation of this pathway regulates opposite responses such as cell survival or neuronal degeneration. These apparent contradictory effects depend on conditions such as the pathway stimuli, the origin of the cells, or the cellular context. In the present review, the authors summarize these findings and discuss their significance with respect to survival or death in the nervous system.

Original languageEnglish
Pages (from-to)175-194
Number of pages20
JournalNeuroscientist
Volume19
Issue number2
DOIs
Publication statusPublished or Issued - Apr 2013

Keywords

  • Motoneuron
  • NF-κB
  • Neurodegenerative disorders
  • Neuronal survival
  • Neurotrophic factors
  • RelA/p65

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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