New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa Butler, Wayne D. Tilley

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

LanguageEnglish
JournalCold Spring Harbor perspectives in medicine
Volume8
Issue number12
DOIs
Publication statusPublished - 3 Dec 2018

Keywords

  • Journal Article
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Centenera, Margaret M. ; Selth, Luke A. ; Ebrahimie, Esmaeil ; Butler, Lisa ; Tilley, Wayne D. / New Opportunities for Targeting the Androgen Receptor in Prostate Cancer. In: Cold Spring Harbor perspectives in medicine. 2018 ; Vol. 8, No. 12.
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New Opportunities for Targeting the Androgen Receptor in Prostate Cancer. / Centenera, Margaret M.; Selth, Luke A.; Ebrahimie, Esmaeil; Butler, Lisa; Tilley, Wayne D.

In: Cold Spring Harbor perspectives in medicine, Vol. 8, No. 12, 03.12.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

AU - Centenera, Margaret M.

AU - Selth, Luke A.

AU - Ebrahimie, Esmaeil

AU - Butler, Lisa

AU - Tilley, Wayne D.

N1 - Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

PY - 2018/12/3

Y1 - 2018/12/3

N2 - Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

AB - Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

KW - Journal Article

KW - Review

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U2 - 10.1101/cshperspect.a030478

DO - 10.1101/cshperspect.a030478

M3 - Review article

VL - 8

JO - Cold Spring Harbor perspectives in medicine

T2 - Cold Spring Harbor perspectives in medicine

JF - Cold Spring Harbor perspectives in medicine

SN - 2157-1422

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