New Findings in Atrial Fibrillation Mechanisms

Dennis H. Lau, Dominik Linz, Prashanthan Sanders

Research output: Contribution to journalReview article

1 Citation (Scopus)


This review focusses on novel findings in atrial fibrillation mechanisms derived from mapping studies. Recent panoramic mapping techniques have identified 2 arrhythmic mechanisms of interest, namely, rotational (rotors) and ectopic focal activations as drivers of atrial fibrillation. Epicardial adipose tissue and fatty infiltration into the myocardium have been described as novel substrates for atrial fibrillation. There is increasing appreciation that the thin atrial walls harbor a complex 3-dimensional electrostructural substrate to contribute to atrial fibrillation sustenance. Further research is warranted to advance the field toward more targeted therapy.

Original languageEnglish
Pages (from-to)563-571
Number of pages9
JournalCardiac Electrophysiology Clinics
Issue number4
Publication statusPublished - 1 Dec 2019
Externally publishedYes


  • Atrial fibrillation
  • Catheter ablation
  • Drivers
  • Mechanism
  • Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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