New drugs for HDL-C disorders: The beginning

My Ngan Duong, Stephen J. Nicholls

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

LanguageEnglish
Pages2947-2951
Number of pages5
JournalCurrent Medicinal Chemistry
Volume21
Issue number25
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • HDL
  • Lipids
  • Risk factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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