Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency

P. S. Cheah, H. S. Ramshaw, Paul Thomas, K. Toyo-Oka, X. Xu, S. Martin, P. Coyle, M. A. Guthridge, F. Stomski, M. Van Den Buuse, A. Wynshaw-Boris, A. F. Lopez, Q. P. Schwarz

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network.

LanguageEnglish
Pages451-466
Number of pages16
JournalMolecular Psychiatry
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • neurodevelopment
  • neuropsychiatric disorder
  • schizophrenia
  • synapse; 14-3-3ζ

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Cheah, P. S., Ramshaw, H. S., Thomas, P., Toyo-Oka, K., Xu, X., Martin, S., ... Schwarz, Q. P. (2012). Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency. Molecular Psychiatry, 17(4), 451-466. https://doi.org/10.1038/mp.2011.158
Cheah, P. S. ; Ramshaw, H. S. ; Thomas, Paul ; Toyo-Oka, K. ; Xu, X. ; Martin, S. ; Coyle, P. ; Guthridge, M. A. ; Stomski, F. ; Van Den Buuse, M. ; Wynshaw-Boris, A. ; Lopez, A. F. ; Schwarz, Q. P. / Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency. In: Molecular Psychiatry. 2012 ; Vol. 17, No. 4. pp. 451-466.
@article{775ce6e09cbd45dca9291e379f1f9b7e,
title = "Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency",
abstract = "Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network.",
keywords = "neurodevelopment, neuropsychiatric disorder, schizophrenia, synapse; 14-3-3ζ",
author = "Cheah, {P. S.} and Ramshaw, {H. S.} and Paul Thomas and K. Toyo-Oka and X. Xu and S. Martin and P. Coyle and Guthridge, {M. A.} and F. Stomski and {Van Den Buuse}, M. and A. Wynshaw-Boris and Lopez, {A. F.} and Schwarz, {Q. P.}",
year = "2012",
month = "4",
day = "1",
doi = "10.1038/mp.2011.158",
language = "English",
volume = "17",
pages = "451--466",
journal = "Molecular psychiatry",
issn = "1359-4184",
publisher = "Nature Publishing Group",
number = "4",

}

Cheah, PS, Ramshaw, HS, Thomas, P, Toyo-Oka, K, Xu, X, Martin, S, Coyle, P, Guthridge, MA, Stomski, F, Van Den Buuse, M, Wynshaw-Boris, A, Lopez, AF & Schwarz, QP 2012, 'Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency', Molecular Psychiatry, vol. 17, no. 4, pp. 451-466. https://doi.org/10.1038/mp.2011.158

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency. / Cheah, P. S.; Ramshaw, H. S.; Thomas, Paul; Toyo-Oka, K.; Xu, X.; Martin, S.; Coyle, P.; Guthridge, M. A.; Stomski, F.; Van Den Buuse, M.; Wynshaw-Boris, A.; Lopez, A. F.; Schwarz, Q. P.

In: Molecular Psychiatry, Vol. 17, No. 4, 01.04.2012, p. 451-466.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency

AU - Cheah, P. S.

AU - Ramshaw, H. S.

AU - Thomas, Paul

AU - Toyo-Oka, K.

AU - Xu, X.

AU - Martin, S.

AU - Coyle, P.

AU - Guthridge, M. A.

AU - Stomski, F.

AU - Van Den Buuse, M.

AU - Wynshaw-Boris, A.

AU - Lopez, A. F.

AU - Schwarz, Q. P.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network.

AB - Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder. 14-3-3ζ-Deficient mice displayed striking behavioural and cognitive deficiencies including a reduced capacity to learn and remember, hyperactivity and disrupted sensorimotor gating. These deficits are accompanied by subtle developmental abnormalities of the hippocampus that are underpinned by aberrant neuronal migration. Significantly, 14-3-3ζ- deficient mice exhibited abnormal mossy fibre navigation and glutamatergic synapse formation. The molecular basis of these defects involves the schizophrenia risk factor, DISC1, which interacts isoform specifically with 14-3-3ζ. Our data provide the first evidence of a direct role for 14-3-3ζ deficiency in the aetiology of neurodevelopmental disorders and identifies 14-3-3ζ as a central risk factor in the schizophrenia protein interaction network.

KW - neurodevelopment

KW - neuropsychiatric disorder

KW - schizophrenia

KW - synapse; 14-3-3ζ

UR - http://www.scopus.com/inward/record.url?scp=84859007028&partnerID=8YFLogxK

U2 - 10.1038/mp.2011.158

DO - 10.1038/mp.2011.158

M3 - Article

VL - 17

SP - 451

EP - 466

JO - Molecular psychiatry

T2 - Molecular psychiatry

JF - Molecular psychiatry

SN - 1359-4184

IS - 4

ER -