Myeloperoxidase, modified lipoproteins, and atherogenesis

Stephen J. Nicholls, Stanley L. Hazen

Research output: Contribution to journalReview articlepeer-review

151 Citations (Scopus)


Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO and its oxidation products predict increased cardiovascular risk. As a result, interest has focused on the potential to target MPO for the development of new risk markers, imaging, and therapies to prevent cardiovascular events.

Original languageEnglish
Pages (from-to)S346-S351
JournalJournal of Lipid Research
Issue numberSUPPL.
Publication statusPublished or Issued - Apr 2009


  • Free radicals
  • High density lipoprotein
  • Oxidant stress
  • Scavenger receptor

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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