Myeloperoxidase levels predict accelerated progression of coronary atherosclerosis in diabetic patients: Insights from intravascular ultrasound

Yu Kataoka, Mingyuan Shao, Kathy Wolski, Kiyoko Uno, Rishi Puri, E. Murat Tuzcu, Stanley L. Hazen, Steven E. Nissen, Stephen J. Nicholls

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: While inflammation has been proposed to contribute to the adverse cardiovascular outcome in diabetic patients, the specific pathways involved have not been elucidated. The leukocyte derived product, myeloperoxidase (MPO), has been implicated in all stages of atherosclerosis. The relationship between MPO and accelerated disease progression observed in diabetic patients has not been studied. Methods: We investigated the relationship between MPO and disease progression in diabetic patients. 881 patients with angiographic coronary artery disease underwent serial evaluation of atherosclerotic burden with intravascular ultrasound. Disease progression in diabetic (n=199) and non-diabetic (n=682) patients, stratified by baseline MPO levels was investigated. Results: MPO levels were similar in patients with and without diabetes (1362 vs. 1255pmol/L, p=0.43). No relationship was observed between increasing quartiles of MPO and either baseline (p=0.81) or serial changes (p=0.43) in levels of percent atheroma volume (PAV) in non-diabetic patients. In contrast, increasing MPO quartiles were associated with accelerated PAV progression in diabetic patients (p=0.03). While optimal control of lipid and the use of high-dose statin were associated with less disease progression, a greater benefit was observed in diabetic patients with lower compared with higher MPO levels at baseline. Conclusions: Increasing MPO levels are associated with greater progression of atherosclerosis in diabetic patients. This finding indicates the potential importance of MPO pathways in diabetic cardiovascular disease.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalAtherosclerosis
Volume232
Issue number2
DOIs
Publication statusPublished - 1 Feb 2014

Keywords

  • Atheroma progression
  • Coronary atherosclerosis
  • Diabetes mellitus
  • Intravascular ultrasound
  • Myeloperoxidase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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