Myeloperoxidase and cardiovascular disease

Stephen J. Nicholls, Stanley L. Hazen

Research output: Contribution to journalShort survey

540 Citations (Scopus)

Abstract

Myeloperoxidase (MPO) is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species. In addition to being an integral component of the innate immune response, evidence has emerged that MPO-derived oxidants contribute to tissue damage during inflammation. MPO-catalyzed reactions have been attributed to potentially proatherogenic biological activities throughout the evolution of cardiovascular disease, including during initiation, propagation, and acute complication phases of the atherosclerotic process. As a result, MPO and its downstream inflammatory pathways represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.

Original languageEnglish
Pages (from-to)1102-1111
Number of pages10
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume25
Issue number6
DOIs
Publication statusPublished - 1 Jun 2005

Keywords

  • Atherosclerosis
  • Free radical
  • Heart failure
  • High-density lipoprotein
  • Low-density lipoprotein
  • Myeloperoxidase
  • Nitric oxide
  • Scavenger receptor
  • Vulnerable plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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