Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

Irith Wiegand, Alexandra K. Marr, Elena B.M. Breidenstein, Kristen N. Schurek, Patrick Taylor, Robert E.W. Hancock

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25 Citations (Scopus)


Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).

Original languageEnglish
Pages (from-to)3810-3813
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Issue number10
Publication statusPublished - 1 Oct 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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