Murine Schnurri-2 controls natural killer cell function and lymphoma development

Junji Yamashita, Chiaki Iwamura, Kunitoshi Mitsumori, Hiroyuki Hosokawa, Tetsuya Sasaki, Munehisa Takahashi, Hitoshi Tanaka, Kenji Kaneko, Asami Hanazawa, Yukiko Watanabe, Kenta Shinoda, Damon Tumes, Shinichiro Motohashi, Toshinori Nakayama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient (Shn-2 -/- ) mice develop CD3-positive lymphoma spontaneously. In Shn-2 -/- mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2 -/- NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2 -/- NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2 -/- NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.

LanguageEnglish
Pages479-486
Number of pages8
JournalLeukemia and Lymphoma
Volume53
Issue number3
DOIs
Publication statusPublished - 1 Mar 2012

Keywords

  • NK cells
  • Schnnuri2
  • Spontaneous lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., ... Nakayama, T. (2012). Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leukemia and Lymphoma, 53(3), 479-486. https://doi.org/10.3109/10428194.2011.625099
Yamashita, Junji ; Iwamura, Chiaki ; Mitsumori, Kunitoshi ; Hosokawa, Hiroyuki ; Sasaki, Tetsuya ; Takahashi, Munehisa ; Tanaka, Hitoshi ; Kaneko, Kenji ; Hanazawa, Asami ; Watanabe, Yukiko ; Shinoda, Kenta ; Tumes, Damon ; Motohashi, Shinichiro ; Nakayama, Toshinori. / Murine Schnurri-2 controls natural killer cell function and lymphoma development. In: Leukemia and Lymphoma. 2012 ; Vol. 53, No. 3. pp. 479-486.
@article{51d638803ec94f5d9a0d11e6fd0275c0,
title = "Murine Schnurri-2 controls natural killer cell function and lymphoma development",
abstract = "Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient (Shn-2 -/- ) mice develop CD3-positive lymphoma spontaneously. In Shn-2 -/- mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2 -/- NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2 -/- NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2 -/- NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.",
keywords = "NK cells, Schnnuri2, Spontaneous lymphoma",
author = "Junji Yamashita and Chiaki Iwamura and Kunitoshi Mitsumori and Hiroyuki Hosokawa and Tetsuya Sasaki and Munehisa Takahashi and Hitoshi Tanaka and Kenji Kaneko and Asami Hanazawa and Yukiko Watanabe and Kenta Shinoda and Damon Tumes and Shinichiro Motohashi and Toshinori Nakayama",
year = "2012",
month = "3",
day = "1",
doi = "10.3109/10428194.2011.625099",
language = "English",
volume = "53",
pages = "479--486",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "3",

}

Yamashita, J, Iwamura, C, Mitsumori, K, Hosokawa, H, Sasaki, T, Takahashi, M, Tanaka, H, Kaneko, K, Hanazawa, A, Watanabe, Y, Shinoda, K, Tumes, D, Motohashi, S & Nakayama, T 2012, 'Murine Schnurri-2 controls natural killer cell function and lymphoma development', Leukemia and Lymphoma, vol. 53, no. 3, pp. 479-486. https://doi.org/10.3109/10428194.2011.625099

Murine Schnurri-2 controls natural killer cell function and lymphoma development. / Yamashita, Junji; Iwamura, Chiaki; Mitsumori, Kunitoshi; Hosokawa, Hiroyuki; Sasaki, Tetsuya; Takahashi, Munehisa; Tanaka, Hitoshi; Kaneko, Kenji; Hanazawa, Asami; Watanabe, Yukiko; Shinoda, Kenta; Tumes, Damon; Motohashi, Shinichiro; Nakayama, Toshinori.

In: Leukemia and Lymphoma, Vol. 53, No. 3, 01.03.2012, p. 479-486.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Murine Schnurri-2 controls natural killer cell function and lymphoma development

AU - Yamashita, Junji

AU - Iwamura, Chiaki

AU - Mitsumori, Kunitoshi

AU - Hosokawa, Hiroyuki

AU - Sasaki, Tetsuya

AU - Takahashi, Munehisa

AU - Tanaka, Hitoshi

AU - Kaneko, Kenji

AU - Hanazawa, Asami

AU - Watanabe, Yukiko

AU - Shinoda, Kenta

AU - Tumes, Damon

AU - Motohashi, Shinichiro

AU - Nakayama, Toshinori

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient (Shn-2 -/- ) mice develop CD3-positive lymphoma spontaneously. In Shn-2 -/- mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2 -/- NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2 -/- NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2 -/- NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.

AB - Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient (Shn-2 -/- ) mice develop CD3-positive lymphoma spontaneously. In Shn-2 -/- mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2 -/- NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2 -/- NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2 -/- NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo.

KW - NK cells

KW - Schnnuri2

KW - Spontaneous lymphoma

UR - http://www.scopus.com/inward/record.url?scp=84857543117&partnerID=8YFLogxK

U2 - 10.3109/10428194.2011.625099

DO - 10.3109/10428194.2011.625099

M3 - Article

VL - 53

SP - 479

EP - 486

JO - Leukemia and Lymphoma

T2 - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 3

ER -

Yamashita J, Iwamura C, Mitsumori K, Hosokawa H, Sasaki T, Takahashi M et al. Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leukemia and Lymphoma. 2012 Mar 1;53(3):479-486. https://doi.org/10.3109/10428194.2011.625099