Multiphasic scaffolds for periodontal tissue engineering

S. Ivanovski, C. Vaquette, S. Gronthos, D. W. Hutmacher, P. M. Bartold

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

For a successful clinical outcome, periodontal regeneration requires the coordinated response of multiple soft and hard tissues (periodontal ligament, gingiva, cementum, and bone) during the wound-healing process. Tissue-engineered constructs for regeneration of the periodontium must be of a complex 3-dimensional shape and adequate size and demonstrate biomechanical stability over time. A critical requirement is the ability to promote the formation of functional periodontal attachment between regenerated alveolar bone, and newly formed cementum on the root surface. This review outlines the current advances in multiphasic scaffold fabrication and how these scaffolds can be combined with cell- and growth factor-based approaches to form tissue-engineered constructs capable of recapitulating the complex temporal and spatial wound-healing events that will lead to predictable periodontal regeneration. This can be achieved through a variety of approaches, with promising strategies characterized by the use of scaffolds that can deliver and stabilize cells capable of cementogenesis onto the root surface, provide biomechanical cues that encourage perpendicular alignment of periodontal fibers to the root surface, and provide osteogenic cues and appropriate space to facilitate bone regeneration. Progress on the development of multiphasic constructs for periodontal tissue engineering is in the early stages of development, and these constructs need to be tested in large animal models and, ultimately, human clinical trials.

Original languageEnglish
Pages (from-to)1212-1221
Number of pages10
JournalJournal of Dental Research
Volume93
Issue number12
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • biomaterials
  • bone
  • cementum
  • periodontal ligament
  • periodontal regeneration
  • regenerative medicine

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ivanovski, S., Vaquette, C., Gronthos, S., Hutmacher, D. W., & Bartold, P. M. (2014). Multiphasic scaffolds for periodontal tissue engineering. Journal of Dental Research, 93(12), 1212-1221. https://doi.org/10.1177/0022034514544301