Multimodal population brain imaging in the UK Biobank prospective epidemiological study

Karla L. Miller, Fidel Alfaro-Almagro, Neal K. Bangerter, David L. Thomas, Essa Yacoub, Junqian Xu, Andreas J. Bartsch, Saad Jbabdi, Stamatios N. Sotiropoulos, Jesper L.R. Andersson, Ludovica Griffanti, Gwenaëlle Douaud, Thomas W. Okell, Peter Weale, Iulius Dragonu, Steve Garratt, Sarah Hudson, Rory Collins, Mark Jenkinson, Paul M. MatthewsStephen M. Smith

Research output: Contribution to journalArticlepeer-review

526 Citations (Scopus)


Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.

Original languageEnglish
Pages (from-to)1523-1536
Number of pages14
JournalNature Neuroscience
Issue number11
Publication statusPublished or Issued - 26 Oct 2016
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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