Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise

Adam G. Thomas, Andrea Dennis, Nancy B. Rawlings, Charlotte J. Stagg, Lucy Matthews, Martyn Morris, Shannon H. Kolind, Sean Foxley, Mark Jenkinson, Thomas E. Nichols, Helen Dawes, Peter A. Bandettini, Heidi Johansen-Berg

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The hippocampus has been shown to demonstrate a remarkable degree of plasticity in response to a variety of tasks and experiences. For example, the size of the human hippocampus has been shown to increase in response to aerobic exercise. However, it is currently unknown what underlies these changes. Here we scanned sedentary, young to middle-aged human adults before and after a six-week exercise intervention using nine different neuroimaging measures of brain structure, vasculature, and diffusion. We then tested two different hypotheses regarding the nature of the underlying changes in the tissue. Surprisingly, we found no evidence of a vascular change as has been previously reported. Rather, the pattern of changes is better explained by an increase in myelination. Finally, we show that hippocampal volume increase is temporary, returning to baseline after an additional six weeks without aerobic exercise. This is the first demonstration of a change in hippocampal volume in early to middle adulthood suggesting that hippocampal volume is modulated by aerobic exercise throughout the lifespan rather than only in the presence of age related atrophy. It is also the first demonstration of hippocampal volume change over a period of only six weeks, suggesting that gross morphometric hippocampal plasticity occurs faster than previously thought.

LanguageEnglish
Pages162-170
Number of pages9
JournalNeuroImage
Volume131
DOIs
Publication statusPublished - 1 May 2016

Keywords

  • Aging
  • Angiogenesis
  • Dentate gyrus
  • Environmental enrichment
  • Exercise
  • Fitness
  • Hippocampus
  • Myelin
  • Neurogenesis
  • Plasticity

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., ... Johansen-Berg, H. (2016). Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. NeuroImage, 131, 162-170. https://doi.org/10.1016/j.neuroimage.2015.10.090
Thomas, Adam G. ; Dennis, Andrea ; Rawlings, Nancy B. ; Stagg, Charlotte J. ; Matthews, Lucy ; Morris, Martyn ; Kolind, Shannon H. ; Foxley, Sean ; Jenkinson, Mark ; Nichols, Thomas E. ; Dawes, Helen ; Bandettini, Peter A. ; Johansen-Berg, Heidi. / Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. In: NeuroImage. 2016 ; Vol. 131. pp. 162-170.
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Thomas, AG, Dennis, A, Rawlings, NB, Stagg, CJ, Matthews, L, Morris, M, Kolind, SH, Foxley, S, Jenkinson, M, Nichols, TE, Dawes, H, Bandettini, PA & Johansen-Berg, H 2016, 'Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise', NeuroImage, vol. 131, pp. 162-170. https://doi.org/10.1016/j.neuroimage.2015.10.090

Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. / Thomas, Adam G.; Dennis, Andrea; Rawlings, Nancy B.; Stagg, Charlotte J.; Matthews, Lucy; Morris, Martyn; Kolind, Shannon H.; Foxley, Sean; Jenkinson, Mark; Nichols, Thomas E.; Dawes, Helen; Bandettini, Peter A.; Johansen-Berg, Heidi.

In: NeuroImage, Vol. 131, 01.05.2016, p. 162-170.

Research output: Contribution to journalArticle

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