Mucopolysaccharidosis II (MPS II) in a Free-Living Kaka (Nestor meridionalis) in New Zealand

Robert D Jolly, Stuart A Hunter, Maurice R Alley, Barbara M King, Adeline A Lau, Paul J Trim, Marten F Snel, Kim M Hemsley

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Abstract

A lysosomal storage disease, identified as a mucopolysaccharidosis, was diagnosed in a free-living kaka (Nestor meridionalis), an endemic New Zealand parrot, which exhibited weakness, incoordination and seizures. Histopathology showed typical colloid-like cytoplasmic inclusions in Purkinje cells and many other neurons throughout the brain. Electron microscopy revealed that storage bodies contained a variety of linear, curved, or circular membranous profiles and electron-dense bodies. Because the bird came from a small isolated population of Kaka in the northern South Island, a genetic cause was deemed likely. Tandem mass spectrometry revealed increased levels of heparan sulfate-derived disaccharides in the brain and liver compared with tissues from controls. Enzymatic assays documented low levels of iduronate-2-sulfatase activity, which causes a lysosomal storage disorder called mucopolysaccharidosis type II or Hunter syndrome. A captive breeding program is currently in progress, and the possibility of detecting carriers of this disorder warrants further investigation.

Original languageEnglish
JournalJournal of wildlife diseases
DOIs
Publication statusE-pub ahead of print - 23 Aug 2021

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