mTORC1 signalling and mRNA translation

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103 Citations (Scopus)

Abstract

Signalling through mTORC1 (mammalian target of rapamycin complex 1) is important in controlling many cell functions, including protein synthesis, which it activates. mTORC1 signalling is activated by stimuli which promote protein accumulation such as anabolic hormones, growth factors and hypertrophic stimuli. mTORC1 signalling regulates several components of the protein synthetic machinery, including initiation and elongation factors, protein kinases which phosphorylate the ribosome and/ or translation factors, and the translation of specific mRNAs. However, there are still important gaps in our understanding of the actions of mTORC1 and the relative contributions that different targets of mTORC1 make to the activation of protein synthesis remain to be established.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalBiochemical Society Transactions
Volume37
Issue number1
DOIs
Publication statusPublished - 26 Jun 2009
Externally publishedYes

Keywords

  • Elongation factor
  • Initiation factor
  • Mammalian target of rapamycin (mTOR)
  • Protein kinase
  • Protein synthesis
  • mRNA

ASJC Scopus subject areas

  • Biochemistry

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