MTORC1 signaling controls multiple steps in ribosome biogenesis

Valentina Iadevaia, Rui Liu, Christopher G. Proud

Research output: Contribution to journalReview articlepeer-review

102 Citations (Scopus)


Ribosome biogenesis is critical for cells to generate the ribosomes they need for protein synthesis in order to survive, grow and proliferate. It is a complex process, involving the coordinated production of four different RNA species and about 80 proteins, as well as their assembly into functional ribosomal subunits. Given its high demand for amino acids and nucleotides, it is also a metabolically expensive process for the cell. The mammalian target of rapamycin complex 1 (mTORC1) is a protein kinases which is activated by nutrients, anabolic hormones and oncogenic signaling pathways. mTORC1 positively regulates several steps in ribosome biogenesis, including ribosomal RNA transcription, the synthesis of ribosomal proteins and other components required for ribosome assembly. mTORC1 can thus coordinate stimuli which promote ribosome production with the various steps involved in this process. Although important advances have been made in our understanding of mTORC1 signaling, major questions remain about the molecular mechanisms by which it regulates ribosome biogenesis.

Original languageEnglish
Pages (from-to)113-120
Number of pages8
JournalSeminars in Cell and Developmental Biology
Publication statusPublished - 1 Dec 2014


  • 5'-TOP
  • MTOR
  • MTOR complex 1
  • Mammalian target of rapamycin
  • RNA polymerase
  • RRNA
  • Rapamycin
  • Ribosomal protein

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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