mTOR and its Downstream Targets

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The mammalian target of rapamycin (mTOR) is a protein kinase that plays key roles in regulating cellular functions. mTOR forms two distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1/2), which phosphorylate different substrates. Rapamycin inhibits many functions of mTORC1. Its use has revealed that mTORC1 regulates protein synthesis, ribosome production, autophagy, gene transcription, and cell growth and division. mTORC1's best-known substrates are proteins involved in protein synthesis. mTORC2 phosphorylates protein kinases such as Akt. Defects in mTOR signaling or its control are involved in various diseases, including cancers, and mTOR signaling is thus a potentially valuable therapeutic target.

Original languageEnglish
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages194-199
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
Publication statusPublished or Issued - 15 Feb 2013
Externally publishedYes

Keywords

  • Autophagy
  • Cancer
  • Cell cycle
  • Cell growth
  • EIF4E
  • MRNA translation
  • MTORC
  • Protein synthesis
  • Rapalog
  • Rapamycin
  • Ribosome biogenesis
  • TSC
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this