MR-DTI and PET multimodal imaging of dopamine release within subdivisions of basal ganglia

A. Tziortzi, G. Searle, C. Tsoumpas, C. Long, P. Shotbolt, E. Rabiner, Mark Jenkinson, R. N. Gunn

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

The basal ganglia is a group of anatomical nuclei, functionally organised into limbic, associative and sensorimotor regions, which plays a central role in dopamine related neurological and psychiatric disorders. In this study, we combine two imaging modalities to enable the measurement of dopamine release in functionally related subdivisions of the basal ganglia. [11C]-(+)-PHNO Positron Emission Tomography (PET) measurements in the living human brain pre- and post-administration of amphetamine allow for the estimation of regional dopamine release. Combined Magnetic Resonance Diffusion Tensor Imaging (MR-DTI) data allows for the definition of functional territories of the basal ganglia from connectivity information. The results suggest that there is a difference in dopamine release among the connectivity derived functional subdivisions. Dopamine release is highest in the limbic area followed by the sensorimotor and then the associative area with this pattern reflected in both striatum and pallidum.

LanguageEnglish
Article number012005
JournalJournal of Physics: Conference Series
Volume317
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011
EventInternational Conference on Image Optimisation in Nuclear Medicine, OptiNM 2011 - Ayia Napa, Cyprus
Duration: 23 Mar 201126 Mar 2011

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Tziortzi, A., Searle, G., Tsoumpas, C., Long, C., Shotbolt, P., Rabiner, E., ... Gunn, R. N. (2011). MR-DTI and PET multimodal imaging of dopamine release within subdivisions of basal ganglia. Journal of Physics: Conference Series, 317(1), [012005]. https://doi.org/10.1088/1742-6596/317/1/012005