Mouse models of gastric cancer

Yoku Hayakawa, James G. Fox, Tamas Gonda, Daniel L. Worthley, Sureshkumar Muthupalani, Timothy C. Wang

Research output: Contribution to journalReview articlepeer-review

51 Citations (Scopus)

Abstract

Animal models have greatly enriched our understanding of the molecular mechanisms of numerous types of cancers. Gastric cancer is one of the most common cancers worldwide, with a poor prognosis and high incidence of drug-resistance. However, most inbred strains of mice have proven resistant to gastric carcinogenesis. To establish useful models which mimic human gastric cancer phenotypes, investigators have utilized animals infected with Helicobacter species and treated with carcinogens. In addition, by exploiting genetic engineering, a variety of transgenic and knockout mouse models of gastric cancer have emerged, such as INS-GAS mice and TFF1 knockout mice. Investigators have used the combination of carcinogens and gene alteration to accelerate gastric cancer development, but rarely do mouse models show an aggressive and metastatic gastric cancer phenotype that could be relevant to preclinical studies, which may require more specific targeting of gastric progenitor cells. Here, we review current gastric carcinogenesis mouse models and provide our future perspectives on this field.

Original languageEnglish
Pages (from-to)92-130
Number of pages39
JournalCancers
Volume5
Issue number1
DOIs
Publication statusPublished or Issued - Mar 2013

Keywords

  • Gastric cancer
  • Helicobacter felis
  • Helicobacter pylori
  • Ins-gas mice
  • Metaplasia
  • Mouse model

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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