Morphine blood concentrations in elderly postoperative patients following administration via an indwelling subcutaneous cannula

T. J. Semple, R. N. Upton, P. E. Macintyre, W. B. Runciman, L. E. Mather

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The pharmacokinetics of morphine in venous blood after a 5 mg bolus dose via an indwelling subcutaneous cannula were characterised in 22 elderly patients undergoing elective major surgery. In a subgroup of seven patients, the kinetics were also characterised after a second 5 mg dose of morphine administered 180 min after the first dose. Blood morphine concentrations following the single dose were highly variable - the coefficients of variation of C(max), T(max) and the AUC up to 180 min (AUC180) were 54, 37 and 39%, respectively, with mean values of 86.6 ng.ml-1, 15.9 min and 3954 ng.ml-1, respectively. These mean values for the second dose were not statistically different to those of the first dose but were more variable. It was concluded that the injection of morphine via an indwelling subcutaneous cannula results in blood concentrations that are comparable to, and as variable as, those arising from intramuscular injection.

LanguageEnglish
Pages318-323
Number of pages6
JournalAnaesthesia
Volume52
Issue number4
DOIs
Publication statusPublished - 1 Jan 1997
Externally publishedYes

Keywords

  • Age factors
  • Analgesics; morphine
  • Pharmacokinetics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Semple, T. J. ; Upton, R. N. ; Macintyre, P. E. ; Runciman, W. B. ; Mather, L. E. / Morphine blood concentrations in elderly postoperative patients following administration via an indwelling subcutaneous cannula. In: Anaesthesia. 1997 ; Vol. 52, No. 4. pp. 318-323.
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Morphine blood concentrations in elderly postoperative patients following administration via an indwelling subcutaneous cannula. / Semple, T. J.; Upton, R. N.; Macintyre, P. E.; Runciman, W. B.; Mather, L. E.

In: Anaesthesia, Vol. 52, No. 4, 01.01.1997, p. 318-323.

Research output: Contribution to journalArticle

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