Molecular mechanisms of atrial fibrosis: implications for the clinic

Shivshankar Thanigaimani, Dennis H. Lau, Thomas Agbaedeng, Adrian D. Elliott, Rajiv Mahajan, Prashanthan Sanders

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Introduction: Recent research has unravelled an increasing list of cardiac conditions and risk factors that may be responsible for the abnormal underlying atrial substrate that predisposes to atrial fibrillation (AF). Atrial fibrosis has been demonstrated as the pivotal structural abnormality underpinning conduction disturbances that promote AF in different disease models. Despite the advancement in our discoveries of the molecular mechanisms involved in the profibrotic milieu, targeted therapeutics against atrial fibrosis remain lacking. Areas covered: This review is focused on detailing the key molecular signalling pathways that contribute to atrial fibrosis including: angiotensin II, transforming growth factor (TGF- ß1), connective tissue growth factor (CTGF) and endothelin-1. We also discussed the potential therapeutic options that may be useful in modulating the abnormal atrial substrate. In addition, we examined the new paradigm of AF care in lifestyle and risk factor management that has been shown to arrest and reverse the atrial remodelling process leading to improved AF outcomes. Expert commentary: The future of AF care is likely to require an integrated approach consisting of aggressive risk factor management in addition to the established paradigm of rate and rhythm management and anticoagulation. Translational studies on molecular therapeutics to combat atrial fibrosis is urgently needed.

Original languageEnglish
Pages (from-to)247-256
Number of pages10
JournalExpert Review of Cardiovascular Therapy
Volume15
Issue number4
DOIs
Publication statusPublished - 3 Apr 2017

Keywords

  • Atrial fibrillation
  • atrial fibrosis
  • atrial remodeling
  • molecular mechanisms
  • risk factor management

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Thanigaimani, S., Lau, D. H., Agbaedeng, T., Elliott, A. D., Mahajan, R., & Sanders, P. (2017). Molecular mechanisms of atrial fibrosis: implications for the clinic. Expert Review of Cardiovascular Therapy, 15(4), 247-256. https://doi.org/10.1080/14779072.2017.1299005