Molecular imaging of myocardial remodeling after infarction.

Johan Verjans, Susanne W.M. van de Borne, Leonard Hofstra, Jagat Narula

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myocardial fibrosis after myocardial infarction plays a major role in cardiac remodeling, development of heart failure, and arrhythmias. Both replacement and interstitial fibrosis are determined by the extent of myofibroblastic proliferation and hence the extent of collagen deposition. It is logical to propose that a molecular imaging strategy that is able to determine the rate of myofibroblastic proliferation should be able to foretell the magnitude of myocardial remodeling and the likelihood of development of heart failure. Of various plausible targets on the proliferating myofibroblasts, receptors for neurohumoral agonists and overexpression of integrin moieties may offer best options for molecular imaging. In this chapter we describe the assessment of angiotensin II receptor and αvβ3 integrin upregulation in a mouse model after myocardial infarction using real time in vivo fluorescence imaging and nuclear imaging.

LanguageEnglish
Pages227-235
Number of pages9
JournalMethods in molecular biology (Clifton, N.J.)
Volume680
Publication statusPublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Verjans, J., van de Borne, S. W. M., Hofstra, L., & Narula, J. (2011). Molecular imaging of myocardial remodeling after infarction. Methods in molecular biology (Clifton, N.J.), 680, 227-235.
Verjans, Johan ; van de Borne, Susanne W.M. ; Hofstra, Leonard ; Narula, Jagat. / Molecular imaging of myocardial remodeling after infarction. In: Methods in molecular biology (Clifton, N.J.). 2011 ; Vol. 680. pp. 227-235.
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Verjans, J, van de Borne, SWM, Hofstra, L & Narula, J 2011, 'Molecular imaging of myocardial remodeling after infarction.', Methods in molecular biology (Clifton, N.J.), vol. 680, pp. 227-235.

Molecular imaging of myocardial remodeling after infarction. / Verjans, Johan; van de Borne, Susanne W.M.; Hofstra, Leonard; Narula, Jagat.

In: Methods in molecular biology (Clifton, N.J.), Vol. 680, 2011, p. 227-235.

Research output: Contribution to journalArticle

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