Molecular distinction between arteries and veins

Jesús Torres-Vázquez, Makoto Kamei, Brant M. Weinstein

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)

Abstract

The vertebrate vascular system is essential for the delivery and exchange of gases, hormones, metabolic wastes and immunity factors. These essential functions are carried out in large part by two types of anatomically distinct blood vessels, namely arteries and veins. Previously, circulatory dynamics were thought to play a major role in establishing this dichotomy, but recently it has become clear that arterial and venous endothelial cells are molecularly distinct even before the output of the first embryonic heartbeat, thus revealing the existence of genetic programs coordinating arterial-venous differentiation. Here we review some of the molecular mechanisms involved in this process.

Original languageEnglish
Pages (from-to)43-59
Number of pages17
JournalCell and Tissue Research
Volume314
Issue number1
DOIs
Publication statusPublished or Issued - Oct 2003
Externally publishedYes

Keywords

  • Arteries
  • Blood vessels
  • Ephrins
  • Notch
  • Vascular endothelial growth factor
  • Veins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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