Modulating immunity as a therapy for bacterial infections

Robert E.W. Hancock, Anastasia Nijnik, Dana J. Philpott

Research output: Contribution to journalReview articlepeer-review

310 Citations (Scopus)


Despite our efforts to halt the increase and spread of antimicrobial resistance, bacteria continue to become less susceptible to antimicrobial drugs over time, and rates of discovery for new antibiotics are declining. Thus, it is essential to explore new paradigms for anti-infective therapy. One promising approach involves host-directed immunomodulatory therapies, whereby natural mechanisms in the host are exploited to enhance therapeutic benefit. The objective is to initiate or enhance protective antimicrobial immunity while limiting inflammation-induced tissue injury. A range of potential immune modulators have been proposed, including innate defence regulator peptides and agonists of innate immune components such as Toll-like receptors and NOD-like receptors.

Original languageEnglish
Pages (from-to)243-254
Number of pages12
JournalNature Reviews Microbiology
Issue number4
Publication statusPublished or Issued - Apr 2012
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this