Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: Comparison with cationic antimicrobial peptides and lipopeptides

Suzana K. Straus, Robert E.W. Hancock

Research output: Contribution to journalReview articlepeer-review

337 Citations (Scopus)


With the steady rise in the number of antibiotic-resistant Gram-positive pathogens, it has become increasingly important to find new antibacterial agents which are highly active and have novel and diversified mechanisms of action. Two classes will be discussed here: the cationic antimicrobial peptides, which are amphiphilic in nature, targeting membranes and increasing their permeability; and lipopeptides, which consist of linear or cyclic peptides with an N-terminus that is acylated with a fatty acid side chain. One member of the cyclic lipopeptide family, the anionic molecule daptomycin, has been extensively studied and is the major focus of this review. Models will be presented on its mode of action and comparisons will be made to the known modes of action of cationic antimicrobial peptides and other lipopeptides.

Original languageEnglish
Pages (from-to)1215-1223
Number of pages9
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number9
Publication statusPublished or Issued - Sep 2006
Externally publishedYes


  • Cationic peptide
  • Daptomycin
  • Gram-positive pathogen
  • Lipopeptide
  • Mechanism of action

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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