MLLT10 rearranged acute leukemia: Incidence, prognosis, and possible therapeutic strategies

Research output: Contribution to journalReview article

Abstract

Rearrangements of the MLLT10 gene occur in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), most commonly T-lineage ALL (T-ALL), in patients of all ages. MLLT10 rearranged (MLLT10r) acute leukemia presents a complex diagnostic and therapeutic challenge due to frequent presentation of immature or mixed phenotype, and a lack of consensus regarding optimal therapy. Cases of MLLT10r AML or T-ALL bearing immature phenotype are at high risk of poor outcome, but the underlying molecular mechanisms and sensitivity to targeted therapies remain poorly characterized. This review addresses the incidence and prognostic significance of MLLT10r in acute leukemia, and how the aberrant gene expression profile of this disease can inform potential targeted therapeutic strategies. Understanding the underlying genomics of MLLT10r acute leukemia, both clinically and molecularly, will improve prognostic stratification and accelerate the development of targeted therapeutic strategies, to improve patient outcomes.

Original languageEnglish
Pages (from-to)709-721
Number of pages13
JournalGenes Chromosomes and Cancer
Volume59
Issue number12
DOIs
Publication statusAccepted/In press - 1 Jan 2020

Keywords

  • AF10
  • MLLT10
  • MLLT10 rearrangements
  • leukemia genomics
  • t(10;11)(p12-13;q14-21)

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this