miR-155 as a potential target of IL-3 signaling in primary AML cells

Teresa Sadras, Chung H. Kok, Michelle Perugini, Hayley S. Ramshaw, Richard J. D'Andrea

Research output: Contribution to journalLetter

3 Citations (Scopus)

Abstract

miR-155 has emerged as one of the key microRNAs (miRNAs) involved in normal and malignant myelopoiesis, and high expression of this miRNA has been flagged as a strong independent prognostic marker in Acute Myeloid Leukemia (AML). While elevated expression of miR-155 has been associated with FLT3-ITD mutations, other mechanisms which may regulate expression of this miRNA in AML remain largely unknown. Here, we present new evidence that miR-155 may be a prime target of IL-3 signaling in primary AML cells. This finding, together with the increasingly apparent role for miR-155 in oncogenesis, and the upregulation of the IL-3 receptor alpha subunit in AML, lead us to propose this pathway may significantly contribute to the leukemic transformation.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalLeukemia Research
Volume57
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • AML
  • interleukin-3
  • miR-155

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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