Microglia in HIV-associated neurological diseases

Jonathan D. Glass, Steve L. Wesselingh

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Human immunodeficiency virus type-1 (HIV-1) is a neurotropic virus linked to a variety of progressive neurologic disorders. This review describes our current understanding of how HIV-1 enters the nervous system and interacts with neuronal and non-neuronal cells to initiate and sustain neurologic dysfunction. The overwhelming majority of cells infected with HIV-1 in the nervous system are microglia/macrophages. Microglial/macrophage infection leads to immune dysregulation as well as production and release of cytotoxic molecules. Interaction of these infected cells with astrocytes may accelerate neurotoxic mechanisms. A hypothetical scenario for how HIV-1 infection leads to neurologic disease is presented.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalMicroscopy Research and Technique
Volume54
Issue number2
DOIs
Publication statusPublished or Issued - 15 Jul 2001
Externally publishedYes

Keywords

  • Astrocytes
  • Cytokines
  • Dementia
  • Macrophage
  • Neurotoxicity

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

Cite this