Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients

Joanna R. Ghali, Kym M. Bannister, Fiona G. Brown, Johan B. Rosman, Kathryn J. Wiggins, David W. Johnson, Stephen McDonald

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

We analyzed data from the Australia and New Zealand Dialysis and Transplant Registry for 1 October 2003 to 31 December 2008 with the aim of describing the nature of peritonitis, therapies, and outcomes in patients on peritoneal dialysis (PD) in Australia. At least 1 episode of PD was observed in 6639 patients. The overall peritonitis rate was 0.60 episodes per patient-year (95% confidence interval: 0.59 to 0.62 episodes), with 6229 peritonitis episodes occurring in 3136 patients. Of those episodes, 13% were culture-negative, and 11% were polymicrobial. Gram-positive organisms were isolated in 53.4% of single-organism peritonitis episodes, and gram-negative organisms, in 23.6%. Mycobacterial and fungal peritonitis episodes were rare. Initial antibiotic therapy for most peritonitis episodes used 2 agents (most commonly vancomycin and an aminoglycoside); in 77.2% of episodes, therapy was subsequently changed to a single agent. Tenckhoff catheter removal was required in 20.4% of cases at a median of 6 days, and catheter removal was more common in fungal, mycobacterial, and anaerobic infections, with a median time to removal of 4 - 5 days. Peritonitis was the cause of death in 2.6% of patients. Transfer to hemodialysis and hospitalization were frequent outcomes of peritonitis. There was no relationship between center size and peritonitis rate. The peritonitis rate in Australia between 2003 and 2008 was higher than that reported in many other countries, with a particularly higher rate of gram-negative peritonitis.

LanguageEnglish
Pages651-662
Number of pages12
JournalPeritoneal Dialysis International
Volume31
Issue number6
DOIs
Publication statusPublished - Nov 2011
Externally publishedYes

Keywords

  • Antibiotics
  • Bacteria
  • Fungi
  • Microbiology
  • Outcomes
  • Peritonitis

ASJC Scopus subject areas

  • Nephrology

Cite this

Ghali, J. R., Bannister, K. M., Brown, F. G., Rosman, J. B., Wiggins, K. J., Johnson, D. W., & McDonald, S. (2011). Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients. Peritoneal Dialysis International, 31(6), 651-662. https://doi.org/10.3747/pdi.2010.00131
Ghali, Joanna R. ; Bannister, Kym M. ; Brown, Fiona G. ; Rosman, Johan B. ; Wiggins, Kathryn J. ; Johnson, David W. ; McDonald, Stephen. / Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients. In: Peritoneal Dialysis International. 2011 ; Vol. 31, No. 6. pp. 651-662.
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Ghali, JR, Bannister, KM, Brown, FG, Rosman, JB, Wiggins, KJ, Johnson, DW & McDonald, S 2011, 'Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients', Peritoneal Dialysis International, vol. 31, no. 6, pp. 651-662. https://doi.org/10.3747/pdi.2010.00131

Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients. / Ghali, Joanna R.; Bannister, Kym M.; Brown, Fiona G.; Rosman, Johan B.; Wiggins, Kathryn J.; Johnson, David W.; McDonald, Stephen.

In: Peritoneal Dialysis International, Vol. 31, No. 6, 11.2011, p. 651-662.

Research output: Contribution to journalArticle

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Ghali JR, Bannister KM, Brown FG, Rosman JB, Wiggins KJ, Johnson DW et al. Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients. Peritoneal Dialysis International. 2011 Nov;31(6):651-662. https://doi.org/10.3747/pdi.2010.00131