Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy

Donald A. Williamson, Eric Ravussin, Ma Li Wong, A. Wagner, A. DiPaoli, Sinan Caglayan, Metin Ozata, Corby Martin, Heather Walden, Cheryl Arnett, Julio Licinio

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Leptin deficiency has been associated with extreme obesity and hyperphagia in rodents and humans. A rare genetic disorder in humans yields the absence of the hormone leptin, extreme obesity, and a ravenous appetite. Reports on these rare cases have indicated that therapy using leptin injections can yield significant weight loss and changes in appetite. The aim of this report on acute leptin therapy in three leptin deficient adults was to provide a microanalysis of changes in eating behavior and ratings of hunger and satiety. In addition to substantial weight loss, 15 weeks of leptin therapy was associated with approximately 50% reduction in food intake and substantial changes in ratings of hunger and satiety before most meals. After short-term leptin therapy, the three participants ate until ratings indicated they were satiated, which was comparable to the ratings before leptin therapy. These findings suggest that one of the primary effects of acute leptin therapy may be to reduce the ravenous hunger associated with leptin deficiency, resulting in reduced food intake and significant weight loss. These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity.

LanguageEnglish
Pages75-80
Number of pages6
JournalAppetite
Volume45
Issue number1
DOIs
Publication statusPublished - Aug 2005

Keywords

  • Food intake
  • Humans
  • Hunger
  • Leptin deficiency
  • Leptin therapy
  • Obesity
  • Weight loss

ASJC Scopus subject areas

  • Psychology(all)
  • Nutrition and Dietetics

Cite this

Williamson, D. A., Ravussin, E., Wong, M. L., Wagner, A., DiPaoli, A., Caglayan, S., ... Licinio, J. (2005). Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. Appetite, 45(1), 75-80. https://doi.org/10.1016/j.appet.2005.01.002
Williamson, Donald A. ; Ravussin, Eric ; Wong, Ma Li ; Wagner, A. ; DiPaoli, A. ; Caglayan, Sinan ; Ozata, Metin ; Martin, Corby ; Walden, Heather ; Arnett, Cheryl ; Licinio, Julio. / Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. In: Appetite. 2005 ; Vol. 45, No. 1. pp. 75-80.
@article{fb6e6247412343dabb74fcf21c051537,
title = "Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy",
abstract = "Leptin deficiency has been associated with extreme obesity and hyperphagia in rodents and humans. A rare genetic disorder in humans yields the absence of the hormone leptin, extreme obesity, and a ravenous appetite. Reports on these rare cases have indicated that therapy using leptin injections can yield significant weight loss and changes in appetite. The aim of this report on acute leptin therapy in three leptin deficient adults was to provide a microanalysis of changes in eating behavior and ratings of hunger and satiety. In addition to substantial weight loss, 15 weeks of leptin therapy was associated with approximately 50{\%} reduction in food intake and substantial changes in ratings of hunger and satiety before most meals. After short-term leptin therapy, the three participants ate until ratings indicated they were satiated, which was comparable to the ratings before leptin therapy. These findings suggest that one of the primary effects of acute leptin therapy may be to reduce the ravenous hunger associated with leptin deficiency, resulting in reduced food intake and significant weight loss. These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity.",
keywords = "Food intake, Humans, Hunger, Leptin deficiency, Leptin therapy, Obesity, Weight loss",
author = "Williamson, {Donald A.} and Eric Ravussin and Wong, {Ma Li} and A. Wagner and A. DiPaoli and Sinan Caglayan and Metin Ozata and Corby Martin and Heather Walden and Cheryl Arnett and Julio Licinio",
year = "2005",
month = "8",
doi = "10.1016/j.appet.2005.01.002",
language = "English",
volume = "45",
pages = "75--80",
journal = "Appetite",
issn = "0195-6663",
publisher = "Academic Press Inc.",
number = "1",

}

Williamson, DA, Ravussin, E, Wong, ML, Wagner, A, DiPaoli, A, Caglayan, S, Ozata, M, Martin, C, Walden, H, Arnett, C & Licinio, J 2005, 'Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy', Appetite, vol. 45, no. 1, pp. 75-80. https://doi.org/10.1016/j.appet.2005.01.002

Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. / Williamson, Donald A.; Ravussin, Eric; Wong, Ma Li; Wagner, A.; DiPaoli, A.; Caglayan, Sinan; Ozata, Metin; Martin, Corby; Walden, Heather; Arnett, Cheryl; Licinio, Julio.

In: Appetite, Vol. 45, No. 1, 08.2005, p. 75-80.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy

AU - Williamson, Donald A.

AU - Ravussin, Eric

AU - Wong, Ma Li

AU - Wagner, A.

AU - DiPaoli, A.

AU - Caglayan, Sinan

AU - Ozata, Metin

AU - Martin, Corby

AU - Walden, Heather

AU - Arnett, Cheryl

AU - Licinio, Julio

PY - 2005/8

Y1 - 2005/8

N2 - Leptin deficiency has been associated with extreme obesity and hyperphagia in rodents and humans. A rare genetic disorder in humans yields the absence of the hormone leptin, extreme obesity, and a ravenous appetite. Reports on these rare cases have indicated that therapy using leptin injections can yield significant weight loss and changes in appetite. The aim of this report on acute leptin therapy in three leptin deficient adults was to provide a microanalysis of changes in eating behavior and ratings of hunger and satiety. In addition to substantial weight loss, 15 weeks of leptin therapy was associated with approximately 50% reduction in food intake and substantial changes in ratings of hunger and satiety before most meals. After short-term leptin therapy, the three participants ate until ratings indicated they were satiated, which was comparable to the ratings before leptin therapy. These findings suggest that one of the primary effects of acute leptin therapy may be to reduce the ravenous hunger associated with leptin deficiency, resulting in reduced food intake and significant weight loss. These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity.

AB - Leptin deficiency has been associated with extreme obesity and hyperphagia in rodents and humans. A rare genetic disorder in humans yields the absence of the hormone leptin, extreme obesity, and a ravenous appetite. Reports on these rare cases have indicated that therapy using leptin injections can yield significant weight loss and changes in appetite. The aim of this report on acute leptin therapy in three leptin deficient adults was to provide a microanalysis of changes in eating behavior and ratings of hunger and satiety. In addition to substantial weight loss, 15 weeks of leptin therapy was associated with approximately 50% reduction in food intake and substantial changes in ratings of hunger and satiety before most meals. After short-term leptin therapy, the three participants ate until ratings indicated they were satiated, which was comparable to the ratings before leptin therapy. These findings suggest that one of the primary effects of acute leptin therapy may be to reduce the ravenous hunger associated with leptin deficiency, resulting in reduced food intake and significant weight loss. These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity.

KW - Food intake

KW - Humans

KW - Hunger

KW - Leptin deficiency

KW - Leptin therapy

KW - Obesity

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=22144457639&partnerID=8YFLogxK

U2 - 10.1016/j.appet.2005.01.002

DO - 10.1016/j.appet.2005.01.002

M3 - Article

VL - 45

SP - 75

EP - 80

JO - Appetite

T2 - Appetite

JF - Appetite

SN - 0195-6663

IS - 1

ER -

Williamson DA, Ravussin E, Wong ML, Wagner A, DiPaoli A, Caglayan S et al. Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy. Appetite. 2005 Aug;45(1):75-80. https://doi.org/10.1016/j.appet.2005.01.002