Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors

C. S. Ruan, Fiona Zhou, Z. Y. He, S. F. Wang, C. R. Yang, Y. J. Shen, Y. Guo, H. B. Zhao, L. Chen, D. Liu, J. Liu, B. T. Baune, Z. C. Xiao, X. F. Zhou

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Mood disorders are a severe health burden but molecular mechanisms underlying mood dysfunction remain poorly understood. Here, we show that wild-type p53-induced phosphatase 1 (Wip1) negatively responds to the stress-induced negative mood-related behaviors. Specifically, we show that Wip1 protein but not its mRNA level was downregulated in the hippocampus but not in the neocortex after 4. weeks of chronic unpredictable mild stress (CUMS) in mice. Moreover, the CUMS-responsive WIP1 downregulation in the hippocampus was restored by chronic treatment of fluoxetine (i.p. 20. mg/kg) along with the CUMS procedure. In addition, Wip1 knockout mice displayed decreased exploratory behaviors as well as increased anxiety-like and depression-like behaviors in mice without impaired motor activities under the non-CUMS condition. Furthermore, the Wip1 deficiency-responsive anxiety-like but not depression-like behaviors were further elevated in mice under CUMS. Although limitations like male-alone sampling and multiply behavioral testing exist, the present study suggests a potential protective function of Wip1 in mood stabilization.

Original languageEnglish
Pages (from-to)12-22
Number of pages11
JournalNeuroscience
Volume293
DOIs
Publication statusPublished - 7 May 2015

Keywords

  • Anxiety-like behavior
  • CUMS
  • Depression-like behavior
  • Exploratory behavior
  • Fluoxetine
  • Wip1

ASJC Scopus subject areas

  • Neuroscience(all)

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